Sisel Natrience Cell Anew Perfecting Serum. Anti Aging, safe, toxin free skin care. Clinically Proven, deeply hydrates, reduces multiple signs of aging, smooths lines and wrinkles, protects against blue light exposure, defends against environmental stressors. Defends Against Environmental Stressors, customized skincare formulated just for you and your skin’s specific needs.

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Applies to USA, Canada, Australia, New Zealand, UK United Kingdom, and Taiwan

$43 USD Customer Price | $47.30 USD Distributor Price

Price other countries (click to expand)

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Where can I purchase Sisel Natrience Cell Anew Perfecting Serum?

Click here to order and create an account as a preferred customer or distributor. Order Sisel Natrience Cell Anew Perfecting Serum online. Distributors pay an average of 10% less than customers. You can order online from any country where Sisel products are sold.


By ordering through this site you will get the following benefits:

  • Assistance ordering online (should you need help) +61 422538801 or email [email protected]
  • Product support 7 days a week
  • Exclusive invitation to our product training group to learn more about the products
  • Weekly updates and stories about the benefits and unique aspects of Sisel products
  • Product knowledge training, and information from myself as a Nutrition and Health Coach and my sponsor, Dr Curt (Chiropractor) who has extensive product and health knowledge
  • Opportunity to work towards getting your products for free and being supported by the fastest growing online Sisel team globally.

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About SISEL Natrience Cell Anew Perfecting Serum

Powered by natural hero ingredients, this skin-smart serum provides deep hydration to replenish and maintain the skin’s moisture balance, while reducing the appearance of aging for a vibrant, youthful look.

The skin-perfecting power of Sisel Natrience Cell Anew Perfecting Serum, with its concentrated natural actives in an anti-aging focused formula, provides proven skin-replenishing and youth-enhancing properties. Lines and wrinkles will appear less visible, skin will feel smoother and look more even, and it will be protected against environmental and cellular stressors with a strengthened appearance. When your skin needs an anti-aging superhero, there’s no better skin protector and perfector than Cell Anew.

Features and Benefits


  • Reduces Multiple Signs of Aging
  • Smooths Lines and Wrinkles
  • Protects Against Blue Light Exposure

  • Defends Against Environmental Stressors


  • Sodium Hyaluronate: Sharing the same mega-hydrating properties as Hyaluronic Acid, Sodium Hyaluronate delivers immediate and long-lasting moisturization to reduce moisture loss while promoting a noticeably smoother, plumper, younger appearance.

  • Hydroxypinacolone Retinoate: As a cell-communicating ingredient in the retinoid family, this gentle retinol alternative smooths lines and wrinkles, evens skin tone and texture, and boosts skin cell turnover.

  • Scenedesmus Rubescens Extract: Stimulating the skin’s own defense against the harmful effects of blue light, this green, freshwater microalgae extract reduces the appearance of hyperpigmentation and redness, protects the skin’s barrier, and helps support collagen synthesis.

  • Xylitylglucoside/Anhydroxylitol/Xylitol: A Xylitol-derived complex of water-binding plant sugars that helps prevent water loss from the skin and provides reinforcement to skin structure for a softer, smoother feel.

  • Olive Squalane: Similar to skin’s natural oil, this plant-derived, environmentally friendly emollient provides nourishing hydration for a soft, glowing complexion and radiant finish.

  • Bacillus Ferment: Sourced from an ancient underwater cave in Mallorca’s Island, this prebiotic supports a balanced microbiome by protecting skin cells from oxidative stress.

  • Natural Green Tea Fragrance: Provides a clean, fresh scent.

Directions for use

Apply morning and night to clean, dry skin. Massage gently over the face and neck until completely absorbed. For those with sensitive skin, test on a small area before applying to the entire face. Avoid close contact with the eye area, eyelids, lips, and upper lip area.

Ingredients List

Water (Aqua), Butylene Glycol, Diisopropyl Adipate, Propanediol, Bacillus Ferment, Leuconostoc/Radish Root Ferment Filtrate, Xylitylglucoside, Sodium Hyaluronate, Hydroxypinacolone Retinoate, Scenedesmus Rubescens Extract, Ethylhexyl Olivate, Squalane, Xylitol, Anhydroxylitol, Tocopherol, Tapioca Starch, Sodium Stearoyl Glutamate, Xanthan Gum, Lecithin, Sclerotium Gum, Pullulan, 1,2-Hexanediol, Pentylene Glycol, Fragrance (Natural). 1 fl. oz. (30 ml)





Discontinue use and consult your health-care provider if any adverse reaction occurs. Do not use if tamper-evident seal is broken. Keep out of the reach of children.

Testimonial and Reviews

Please email me for testimonials about this product: Sisel International Distributor, Nutrition and Health Coach Katie – [email protected]

Additional Information

  • Clinically Tested
  • Dermatologist Tested and Approved
  • SiselSafe
  • No Animal Testing


Question and Answer:

Q: How does Cell Anew Perfecting Serum support skin health?

A: Effective hydration and a strong barrier, as well as smooth and strong-looking and -feeling skin, are all part of what gives your skin a healthy, youthful glow. Cell Anew Perfecting Serum provides intense hydration with Sodium Hyaluronate and helps defend against multiple signs of skin aging with Hydroxypinacolone Retinoate. These two powerhouse ingredients significantly support skin health and vitality.

Q: What are the key benefits of Cell Anew Perfecting Serum?

A: The aging process causes visible changes on the skin’s surface as well as changes we can’t see below the surface. Cell Anew Perfecting Serum supports multiple skin surface layers. It promotes a noticeably smoother, plumper appearance through intense hydration. Lines and wrinkles that become more prominent with age are visibly reduced, rough skin texture is improved, and skin is protected from the harmful effects of blue light and environmental exposure.

Q: What is a serum, and why is Cell Anew Perfecting Serum important in my skincare routine?

A: Serums are highly concentrated formulations designed to absorb quickly into the skin, delivering an intensive dose of ingredients. Serums are light, easily absorbed liquids added to your skincare regimen during your treatment step, after cleansing and before moisturizing.

Q: What is the difference between a serum and a booster?

A: A serum is a blend of active ingredients designed for skin health. Serums like Cell Anew address common skin complaints and tackle multiple skin concerns at once with comprehensive anti-aging benefits. A booster provides a targeted treatment, focusing on the unique capabilities of high-concentration hero ingredients.

Q: What is the difference between Sodium Hyaluronate and Hyaluronic Acid?

A: Hyaluronic Acid is a naturally occurring component found throughout the body’s connective tissue that gives your skin structure and is responsible for a plump, hydrated look. With its optimized ratio of seven unique molecular weights to penetrate various skin surface layers, the sister to Hyaluronic Acid – Sodium Hyaluronate – absorbs into your skin even easier than Hyaluronic Acid and is designed to provide maximum moisturization and help stimulate your skin to produce more of this vital element for deeper moisturization and younger-looking skin. Clinical studies performed on Sodium Hyaluronate demonstrate that it reduces moisture loss within the skin by 32% in 24 hours.

Q: What is the difference between Hydroxypinacolone Retinoate and Retinol?

A: Hydroxypinacolone Retinoate is a powerful retinoid, or Vitamin A derivative. It’s much gentler than traditional retinol, which can cause redness and irritation, but provides the same potent anti-aging and blemish-reducing benefits. It visibly reduces lines and wrinkles, evens the appearance of skin tone and texture, boosts the turnover rate of skin cells, and strengthens the skin’s barrier. Clinical studies performed on Hydroxypinacolone Retinoate demonstrate that it smooths lines and wrinkles by 14% within 28 days.

Q: What is blue light, and what are its negative effects on my skin?

A: Also known as high-energy light, blue light comes from computer and phone screens, other digital devices, and the main source – the sun. Blue light can stimulate the production of free radicals in the skin, which can accelerate the appearance of aging, including breaking down collagen and creating hyperpigmentation.

Q: How does Cell Anew Perfecting Serum protect against damage from blue light?

A: Cell Anew Perfecting Serum is formulated with the microalgae ingredient, Scenedesmus Rubescens Extract. Living in freshwater lakes, this unique organism has developed self-defense capabilities against a harsh environment. Formulated into Cell Anew, it helps stimulate the skin’s own defense against the damaging visible effects of blue light exposure.

Q: When should I use Cell Anew Perfecting Serum?

A: Use Cell Anew morning and night, after cleansing, before or combined with Natrience boosters, and before moisturizing.

Q: How do I choose which serum or booster to add to my Natrience routine, and when to add them?

A: Consider adding one serum or booster at a time and allowing a two-week period for your skin to adjust before adding another. A good starting point is Cell Anew Perfecting Serum, formulated to support healthy skin and reduce multiple signs of aging. Then consider adding a booster that matches your main skin concerns: Go Bright to brighten skin and reduce the appearance of dark spots or discoloration; or Go Clear to reduce the appearance of blemishes, slough off dead surface skin and clarify skin tone; or Go Firm to plump skin, support and protect your skin’s collagen and elastic network, and provide a firm, lifted appearance.



These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Last Updated on June 22, 2024 by Katie Sisel Distributor